In vitro Evaluation of Inhibitory Potency of Galium sinaicum (Delile ex Decne) Boiss. Against Oxidation, Inflammation, and Enzymes Linked Diabetes Mellitus Type II

Abstract

To study the control ability of Galium sinaicum on diabetes mellitus type II. In vitro, antioxidant, anti- inflammatory, α-amylase and α-glucosidase inhibitory activity of Galium sinaicum were evaluated. 80% hydroethanolic extract of Galium sinaicum (GsEE)  possessed potent to moderate α-amylase and α-glucosidase inhibitory potency (78.95 and 60.02%) at 500µg/ml recording comparable IC 50 value of 57.84 ± 3.18μg/ml and 118.65± 1.04µg/ml, with acarbose, respectively. GsEE inhibited lysis of RBC induced by hypotonic solution, recording percentage of 81.93% comparing with aspirin (95.83%) at concentration 1000µg/ml with notable IC 50 value (48.05±0.48µg/ml) comparing with aspirin. GsEE highly succeeded comparing to gallic acid in neutralising DPPH radicals at concentration 300µg/ml till 700µg/ml, scavenging potency was ranged about 93%, recording IC 50 value of 120.6µg/ml comparing with gallic acid (2.8 μg/ml). Regarding to current study Galium sinaicum herb was proved to be antidiabetic controller, what support claims of being used as medicinal herbal tea for diabetics in Saint Catherine area in Saini, Egypt.