Anti-Hyperglycemic and Antioxidant Effect of Peach (Prunus Persica L.) Seed Extract
Keywords:Peach (Prunus persica L.) kernel extract, Streptozotocin induced, Antioxidant activity
The main objective of this work is to evaluate the anti-diabetic activity and antioxidant effect of peach (Prunus persica L.) seed extract. In 2013, 382 million adults were diagnosed with diabetes worldwide. This number is expected to grow to 592 million in 2035. People with diabetes are at increased risk of macro -vascular and micro- vascular, as well as early mortality. In the present study adult male albino rats average (140 g) were divided into three groups: Group I: control; Group II: streptozotocin-induced diabetic; Group III: diabetic rats treated with peach seed extract, administered via an intragastric tube (0.6 ml/rat), at a dose of 150 mg/kg for 20 consecutive days after the induction of diabetes mellitus. Characterization of TBARS, carbonylated proteins, were measured in the plasma and in the supernatant of liver homogenisates, and superoxide dismutase and catalase were measured in the haemolysates of
RBCs and supernatant of liver homogenisates. The results showed that oral administration of peach seed extract (150 mg/kg/day) reduced the levels of lipid peroxides and carbonylated proteins and improved the antioxidant activity in plasma and hepatic compared with the diabetic control rats. These results showed that the peach seed extract enhanced the antioxidant defense against reactive oxygen species produced under hyperglycemic conditions in diabetic adult male albino rats, also hence protecting the liver cells. Also, the results indicate that peach seed extract possessed considerable in vitro anti diabetic activity.
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