Optimization of Electro Spinning Parameters and Cytotoxicity Evaluation of Titanium Dioxide Nanofibers to be Used as a Biomaterial
Keywords:Polyvinyl pyrrolidone, titanium dioxide nanofibers, electro spinning, cytotoxicity
The TiO2 nano fibers were prepared using the conventional sol gel method and the electro spinning technique. Also Polyvinyl pyrrolidone (PVP) polymer using a combination of sol-gel and electro spinning techniques. The effects of sol-gel and electro spinning on TiO2/PVP nanofibers diameter, in addition to polyvinyl pyrrolidone (PVP) concentration, needle Tip-to-collector distance and applied
voltage were evaluated. The optimum combination was determined to be a 10% PVP concentration, with the needle tip-to-collector distance 10 cm, and the applied voltage at 20 kV. The cytotoxicity of the prepared fibers was evaluated using fibroblasts and the results showed that, the fibers increased the cell viability of human normal fibroblasts (BJ1 cells), which indicates that, it can be safely used as a biomaterial.
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