Nanoformulation of Cedarwood Oil and Its Fungicidal Activity against Fusarium solani and Alternaria tenuis
Keywords:Fungicide, nanoemulsion, Cedarwood oil, Arabic gum, F. solani, Alternaria tenuis
Plant pathogens are a major challenge to plant health, yield, and consequently food availability, food security, and human health. Therefore, newly natural or green fungicides in nanoformulation offer a well alternative to synthetic fungicides, with high activity and lower impact on humans and the ecosystem. This study aimed to prepare cedarwood oil nanoemulsions and evaluate their fungicidal
activity against F. solani and Alternaria tenuis. In addition, acute oral toxicity on rats was studied. Nanoemulsion of cedarwood oil was prepared under different ratios and conditions of sonication time, tween 80, and Arabic gum. Four samples (A2, B2, C2, and D2) have high stability droplet size diameters of 129.9, 162.2, 124.4, and 224.2 nm. Samples with lower droplet sizes (A2 and C2) were used for the fungicidal activity study. These samples caused high inhibition in growth and the IC50 accounts for 3.57 % and 2.41 % against F. solani and 1.25% and 2.22% against Alternaria tenuis, respectively. These results showed that Cedarwood oil nanoemulsion of sample A2 (oil: tween at ration 1:1) and sample C2 (oil: Arabic gum: tween at ratio 1:1:1) with 10 minutes sonication time has high fungicidal activity against F. solani and Alternaria tenuis. There is no singes of toxicity or mortality in treated male rats. These results have important implications for the development of green nano fungicides as a safe and effective antifungal as an alternative to synthetic fungicides in green-integrated pest management programs.
This work is licensed under a Creative Commons Attribution 4.0 International License.