Hepatoprotective Effect of Lavandula dentata leaves extracts on Thioacetamide- Induced hepatic fibrosis in male albino mice
Keywords:Lavandula dentate, leaves extracts, liver, thioacetamide (TAA), male, mice
This study is to investigate the effect of L. dentata leaves extracts on experimental liver fibrosis induced by thioacetamide (TAA) in male albino mice. The experimental mice were divided into four groups. The mice of the first group were served as control. The experimental animals of the second group were given 150 mg/kg body weight of TAA by intraperitoneal injection, twice weekly, for 8
weeks. The mice of the third group were exposed to TAA and supplemented with L. dentata leaves extracts. The animals of the fourth group were supplemented with L. dentata leaves extracts. The levels of plasma alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase were significantly decreased. Histopathological evaluations of hepatic sections
from mice treated with TAA showed severe alterations including increase of fibrogenesis processes with structural damage. Administration of L. dentata leaves extracts reduced extent and development of fibrous septa, liver cells change, and biochemical alterations in mice exposed to TAA. The present findings suggests that the supplementation of these extract may act as antioxidant agents and could be an excellent adjuvant support in the therapy of hepatic fibrosis.
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