Cardioprotective Effect of Moringa Oil and Okra Oil in Male Rats Exposed to Thioacetamide

Authors

  • Atef M. Al-Attar Princess Dr. Najla Bint Saud Al-Saud Center for Excellence Research in Biotechnology, King Abdulaziz University, Jeddah, Saudi Arabia. Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Isam M. Abu Zeid Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Khalid S. Alotaibi Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Keywords:

Thioacetamide, Cardiotoxicity, Moringa Oil, Okra Oil, Antioxidant, Rats

Abstract

Currently, the rate of pollution, pollutants and toxic chemicals in the environment is increasing, which poses a threat to living organisms. Toxic chemicals affect the functions of the body's organs negatively. Plant extracts and natural products are considered to have effective nutritional and medicinal benefits. Recently, there is an increasing interest in plant extracts and natural products and
their effectiveness in treating many diseases. The principal aim of the present study was occurred to evaluate the protective influence of moringa oil and okra oil against thioacetamide (TAA) induced cardiotoxicity in Wistar male rats. Experimental rats were divided into six groups. Rats of group 1 were used as controls. Group 2 was treated with TAA (300 mg/kg body weight). Group 3 was exposed to moringa oil (800 mg/kg body weight) plus TAA. Group 4 was treated with okra oil (800 mg/kg body weight) plus TAA. Groups 5 and 6 were treated with moringa oil and okra oil respectively. TAA treatment caused significant increases of serum creatin kinase (CK), lactate dehydrogenase (LDH) levels in group 2, while the levels of serum reduced glutathione (GSH) and superoxide dismutase (SOD) were statistically decreased. Administration of moringa oil and okra oil reduced the severity alterations of these parameters. These new results indicate that moringa oil and okra oil represent protective effect against cardiotoxicity induced by TAA due to their antioxidant roles.

Published

2022-03-20