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April-June 2021

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Differential Expression of Polarization in Odontoblasts and Epithelial cells

Gamal Eldeen Zulhemma Elsharkawy

ABSTRACT: Cell polarity identifies the asymmetry of a cell. Various types of cells, including odontoblasts and epithelial cells, polarize to fulfill their destined functions. Odontoblast polarization is a prerequisite and fundamental step for tooth development and tubular dentin formation. Current knowledge of odontoblasts polarization, however, is very limited, which greatly impedes the development of novel approaches for regenerative endodontics. Compared to odontoblasts, epithelial cell polarization has been extensively studied over the last several decades. The knowledge obtained from epithelia polarization has been found applicable to other cell types, which is particularly useful considering the remarkable similarities of the morphological and compositional features between polarized odontoblasts and epithelia. In this review, we first discuss the characteristics, the key regulatory factors, and the process of epithelial polarity. Next, we compare the known facts of odontoblast polarization with epithelial cells. Lastly, we clarify knowledge gaps in odontoblast polarization and propose the directions for future research to fill the gaps, leading to the advancement of regenerative endodontics.

[ FULL TEXT PDF 234-241 ] DOI: 10.36632/csi/2021.10.2.22

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Antifibrotic Effects of Quercetin and Adenosine Deaminase Inhibitor on Thioacetamide-Induced Liver Fibrosis Mediated By P53 and NF-Kβ Gene Expression

Marwa A. Magdy, Hossam El-Din M. Omar, Sary Kh. Abdel-Ghaffar 3 and Ahmed Th. Ibrahim

ABSTRACT: Potent hepatotoxic chemicals such as thioacetamide (TAA) are used to evaluate hepatoprotective agents. Here we investigate the antifibrotic potential of quercetin (QU) as antioxidant and Erythro-9- (2-hydroxy-3-nonyl) adenine (EHNA) as adenosine deaminase inhibitor against thioacetamide- induced liver fibrosis in male rats. Fifty mature male rats divided into 5 groups: Group I: served as a control was intraperitoneally (IP) injected with Dimethyl sulfoxide (DMSO) by 0.5 ml/rat. Group II: rats were injected IP with TAA (200 mg/kg) twice a week for 3 months. Group III: rats were injected IP with QU (100 mg/kg) 30 min before TAA injection Group IV: rats were injected IP with EHNA (150 μM/kg) 30 min before TAA injection. Group V: rats injected IP with QU (100 mg/kg) and EHNA (150 μM/kg) 30 min before TAA injection. TAA administration causes hepatic necrosis, increases in liver function enzymes, increases in hepatic lipid peroxidation, decrease in glutathione level and increase in the gene expression of tumor protein (P53) and Nuclear Factor-kappa Beta (NF-kβ). With administration of QU alone, EHNA alone or the combination of both significantly attenuated liver fibrosis induced by TAA through decrease of liver biomarkers, improving the redox state of the tissue as well as hindered the expression of inflammation and apoptosis-related genes. Finally, it can be concluded that QU alone, EHNA alone or the combination of both have protective effects against TAA-induced hepatic fibrosis.

[ FULL TEXT PDF 242-252 ] DOI: 10.36632/csi/2021.10.2.23

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Mineralogy, Geochemistry and Alteration Characteristics of the Radioactive Granite at Wadi El Reddah Area, North Eastern Desert, Egypt

Ahmed Ali Abu Steet

ABSTRACT: Ground radiometric survey in Wadi El Reddah area, which represents the north eastern parts of Gabal Gattar batholith in the North Eastern Desert of Egypt, clearly distinguishes two anomalous bodies in the hydrothermally altered alkali feldspar granite. Localized uranium mineralization, formed predominantly of kasolite, is associated with zircon, fluorite, and cotunnite, accompanied by intense hematitization, desilicification, chloritization and K-metasomatism of the original host granite. The geochemical data showing that the mean U (174 ppm) in the mineralized domain is increased in abundances relative to the less altered granite. Mean Th (43 ppm), on the other hand, is relatively remains constant and mean Th/U ratios changes from 2.6 in the less altered granite to 0.27 in the mineralized zones. During mineralization processes, most of major and trace elements are mobilized to some extent where elements such as K, Rb, Zr, Zn and Pb are enriched, while Si, Sr and REE are depleted. The formation of secondary uranium mineralization are generally attributed to wet climatic episodes prevailed at the late Quaternary in Egypt.

[ FULL TEXT PDF 253-264 ] DOI: 10.36632/csi/2021.10.2.24

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Assessment of Racial and Socioeconomic Status as Factors Affecting Emergence of Permanent Teeth among a Group of Egyptian and Sudanese Children

Eman Korayem, Nancy Ahmed Khattab, Mohammed Abou El-Yazeed, Nayera E Hassan and Tamer Mahmoud Abd El Wahab

ABSTRACT: Introduction: Tooth emergence is influenced by various factors, one of them is socioeconomic status (SES) and race. This study was aimed to assess the relationship between the number of permanent teeth emerged with socioeconomic status in 5-13 years old Egyptian and Sudanese Nubian children. Methods: this study was a cross sectional carried out on 2000 Egyptian and Sudanese Nubian children, The Socioeconomic status of the participants was determined using Fahmy modified index. This index was designed for evaluation of the social status of families, to be used in health research in Egypt. Results: A negative week correlation was found between socioeconomic status and emergence of permanent teeth in the whole studied sample r = -0.056 in Egyptian children and -0.101 in Sudanese Nubian children. Conclusion: There is a relationship between socioeconomic status and the number of permanent teeth emerged in Egyptian and Sudanese Nubian children aged 5-13 years old. The higher the socioeconomic status of a child, the less number of permanent teeth emerged. Sudanese Nubian children have earlier permanent teeth emergence than Egyptian children

[ FULL TEXT PDF 265-275 ] DOI: 10.36632/csi/2021.10.2.25

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Substitution of Conventional Organic and Chemical Fertilization by Some Biostimulants and Their Effect on Growth, Flowering and Bulb Productivity ofNarcissus Tazetta Plant.

Ola Awad Amin, Magdy Azmy Barsoom and Zakaria Bastawy

ABSTRACT: A study was carried out at El-Mathana Agricultural Research Station, Luxor Governorate, Egypt in two seasons of 2017 and 2018 where plants of Narcissus tazetta were treated with NPK at 2 g/plant, salicylic acid at 100 and 200 ppm, garlic extract at 125 ml/plant, ascorbic acid at 100 and 200 ppm, citric acid at 100 and 200ppm and yeast at 3 and 5 g/plant. Results showed that plants treated with salicylic acid at 200 ppm (after transaction with NPK) achieved the highest value of all morphological characteristics of plants i.e. plant height, number of leaves per plant, flowering duration, number of bulblets per plant, bulb diameter, bulb fresh weight as well as fresh and dry weight of leaves beside chemical content of chlorophyll a,b and carotenoids in addition to the percentage of nitrogen, phosphorus and potassium compared to the control. Applying salicylic acid at 100 ppm (after transaction with NPK) had the highest stimulate effect on fresh, dry weight, diameter and longevity of cut flower, also, it had a strong effect in increasing fresh, dry and length of scape of flowers with raising chemical traits. This experiment clarified the importance of natural materials for increasing the efficiency of the vegetative and flower qualities of Narcissus tazetta.

[ FULL TEXT PDF 276-294 ] DOI: 10.36632/csi/2021.10.2.26

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